InnateDB Protein
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IDBP-623668.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ube2i
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Protein Name
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ubiquitin-conjugating enzyme E2I
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Synonyms
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5830467E05Rik; F830028O17Rik; UBC9; Ubce2i; Ubce9;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000134491
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InnateDB Gene
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IDBG-151396 (Ube2i)
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Protein Structure
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Function |
Accepts the ubiquitin-like proteins SUMO1, SUMO2 and SUMO3 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2 or CBX4. Can catalyze the formation of poly- SUMO chains. Essential for nuclear architecture, chromosome segregation and embryonic viability. Necessary for sumoylation of FOXL2 and KAT5 (By similarity). Sumoylates p53/TP53 at 'Lys-386'. {ECO:0000250, ECO:0000269PubMed:16326389, ECO:0000269PubMed:17187077, ECO:0000269PubMed:22214662}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Mainly nuclear. In spermatocytes, localizes in synaptonemal complexes. Recruited by BCL11A into the nuclear body.
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Disease Associations |
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Tissue Specificity |
Present in spleen, kidney, lung, brain, heart and testis (at protein level). {ECO:0000269PubMed:9409784}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.
They are also associated with 280 interaction(s) predicted by orthology.
Experimentally validated |
Total |
49
[view]
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Protein-Protein |
49
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
280 [view]
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Molecular Function |
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Biological Process |
GO:0000122
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negative regulation of transcription from RNA polymerase II promoter
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GO:0006464
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cellular protein modification process
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GO:0007059
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chromosome segregation
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GO:0007067
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mitotic nuclear division
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GO:0007275
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multicellular organismal development
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GO:0010469
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regulation of receptor activity
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GO:0016032
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viral process
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GO:0016567
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protein ubiquitination
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GO:0016925
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protein sumoylation
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GO:0033145
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positive regulation of intracellular steroid hormone receptor signaling pathway
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GO:0043161
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proteasome-mediated ubiquitin-dependent protein catabolic process
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GO:0045892
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negative regulation of transcription, DNA-templated
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GO:0051091
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positive regulation of sequence-specific DNA binding transcription factor activity
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Cellular Component |
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PDB ID |
MGI:107365
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P63280
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PhosphoSite |
PhosphoSite-P63280
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TrEMBL |
G3UYP0
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UniProt Splice Variant |
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Entrez Gene |
22196
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UniGene |
Mm.240044
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RefSeq |
XP_006524111
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MGI ID |
2VRR
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MGI Symbol |
Ube2i
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OMIM |
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CCDS |
CCDS28513
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HPRD |
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IMGT |
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EMBL |
AC122454
AK003141
AK005058
AK011239
AK012282
AK088508
AK150575
AK160014
AK160988
AK165606
AK165615
AK166016
AK166657
AK166930
AK167162
AK168212
AK168706
AK168766
AY491413
U31934
U76416
U82627
U94402
X97575
X99739
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GenPept |
AAB02182
AAB18790
AAB48446
AAB52424
AAS21651
BAB22599
BAB23783
BAB27487
BAB28140
BAC40395
BAE29670
BAE35560
BAE36134
BAE38290
BAE38295
BAE38521
BAE38922
BAE39124
BAE39303
BAE40170
BAE40548
BAE40602
CAA66188
CAA68072
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