InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ppm1l

Summary

InnateDB Gene

IDBG-151460.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppm1l

Gene Name

protein phosphatase 1 (formerly 2C)-like

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027784

Encoded Proteins

IDBP-151462

protein phosphatase 1 (formerly 2C)-like

IDBP-536508

protein phosphatase 1 (formerly 2C)-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163590:
PPM1L, or PP2CE, belongs to the PP2C group of serine/threonine phosphatases, which are distinguished from other phosphatases by their structure, absolute requirement for Mg(2+) or Mn(2+), and insensitivity to okadaic acid. PP2Cs regulate stress-activated protein kinase (SAPK; see MIM 601158) signaling cascades that respond to extracellular stimuli (Jin et al., 2004 [PubMed 15560375]).[supplied by OMIM, Apr 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:69316861-69560802

Strand

Forward strand

Band

Transcripts

ENSMUST00000029355	ENSMUSP00000029355
ENSMUST00000134037	ENSMUSP00000120467
ENSMUST00000128637

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000165	MAPK cascade
GO:0006470	protein dephosphorylation
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0016311	dephosphorylation