Version 5.4
Mus musculus Protein: Ppm1l
Summary
InnateDB Protein IDBP-151462.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ppm1l
Protein Name protein phosphatase 1 (formerly 2C)-like
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000029355
InnateDB Gene IDBG-151460 (Ppm1l)
Protein Structure
UniProt Annotation
Function Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. {ECO:0000269PubMed:12556533}.
Subcellular Localization Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed in brain, heart, testis, liver, lung and skeletal muscle. {ECO:0000269PubMed:12556533}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000165 MAPK cascade
GO:0006470 protein dephosphorylation
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:2139740
InterPro IPR001932 Protein phosphatase 2C (PP2C)-like domain
PFAM PF00481
PF07228
PRINTS
PIRSF
SMART SM00331
SM00332
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BHN0
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 242083
UniGene Mm.487910
RefSeq NP_848841
MGI ID
MGI Symbol Ppm1l
OMIM
CCDS CCDS17405
HPRD
IMGT
EMBL AF117832 AK028275 AK032529 AK035912 AK045724 AK131646 AK147876 AK220523 AY184801 BC096031
GenPept AAD17235 AAH96031 AAO43055 BAC25853 BAC27913 BAC29241 BAC32472 BAD90308 BAE20738 BAE28196

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca