InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Max

Summary

InnateDB Gene

IDBG-151490.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Max

Gene Name

Max protein

Synonyms

AA960152; AI875693; bHLHd4; bHLHd5; bHLHd6; bHLHd7; bHLHd8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000059436

Encoded Proteins

IDBP-151492

Max protein

IDBP-260375

Max protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125952:
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:76937269-76962248

Strand

Reverse strand

Band

Transcripts

ENSMUST00000082136	ENSMUSP00000080778
ENSMUST00000110395	ENSMUSP00000106025

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	17 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	78 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0032403	protein complex binding
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0046982	protein heterodimerization activity
GO:0046983	protein dimerization activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006461	protein complex assembly
GO:0009267	cellular response to starvation
GO:0010243	response to organonitrogen compound
GO:0010629	negative regulation of gene expression
GO:0032868	response to insulin
GO:0048678	response to axon injury
GO:0051402	neuron apoptotic process
GO:0060041	retina development in camera-type eye
GO:0071375	cellular response to peptide hormone stimulus