Homo sapiens Gene: MAX | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-9524.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | MAX | ||||||||||||||||||||||
Gene Name | MYC associated factor X | ||||||||||||||||||||||
Synonyms | bHLHd4 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000125952 | ||||||||||||||||||||||
Encoded Proteins |
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
MYC associated factor X
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 14:65006174-65102695 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q23.3 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 817 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||
REACTOME |
Cyclin A:Cdk2-associated events at S phase entry pathway
Cyclin E associated events during G1/S transition pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G1/S Transition pathway
Cell Cycle pathway
Cell Cycle, Mitotic pathway
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KEGG |
MAPK signaling pathway pathway
Small cell lung cancer pathway
Pathways in cancer pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Validated targets of C-MYC transcriptional repression
Validated targets of C-MYC transcriptional activation
Signaling events mediated by HDAC Class I
C-MYC pathway
Regulation of nuclear SMAD2/3 signaling
Regulation of Telomerase
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.285354 | ||||||||||||||||||||||
RefSeq | NM_002382 NM_145112 NM_145113 NM_145114 NM_197957 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS41965 CCDS9770 CCDS9771 CCDS9772 CCDS9774 | ||||||||||||||||||||||
HPRD | 01113 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||