Version 5.4
Mus musculus Gene: Tpsg1
Summary
InnateDB Gene IDBG-151783.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Tpsg1
Gene Name tryptase gamma 1
Synonyms Prss31; Tmt
Species Mus musculus
Ensembl Gene ENSMUSG00000033200
Encoded Proteins
IDBP-151785
tryptase gamma 1
IDBP-539464
tryptase gamma 1
IDBP-537347
tryptase gamma 1
IDBP-535162
tryptase gamma 1
IDBP-538159
tryptase gamma 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000116176:
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:25369273-25374442
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000024999 ENSMUSP00000024999
ENSMUST00000160377 ENSMUSP00000124008
ENSMUST00000160485 ENSMUSP00000124721
ENSMUST00000162021 ENSMUSP00000125180
ENSMUST00000160920 ENSMUSP00000123828
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
Orthologs
Species
Homo sapiens
Gene ID
Gene Order
ENSG00000116176
View Gene Order
Cross-References
SwissProt
TrEMBL E0CXD8 G3XA07 Q99N26
UniProt Splice Variant
Entrez Gene 26945
UniGene Mm.180108
RefSeq XM_006524362 NM_012034 XM_006524358 XM_006524359 XM_006524360 XM_006524364
OMIM
CCDS CCDS28518
HPRD
IMGT
MGI ID MGI:1349391
MGI Symbol Tpsg1
EMBL AC122454 AF226868 CH466606
GenPept AAG53458 EDL22423
RNA Seq Atlas 26945

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca