Version 5.4
| Homo sapiens Gene: TPSG1 | |||||||||
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| Summary | |||||||||
| InnateDB Gene | IDBG-8597.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | TPSG1 | ||||||||
| Gene Name | tryptase gamma 1 | ||||||||
| Synonyms | PRSS31; TMT; trpA | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Gene | ENSG00000116176 | ||||||||
| Encoded Proteins |
tryptase gamma 1
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||
| Entrez Gene | |||||||||
| Summary |
Tryptases comprise a family of trypsin-like serine proteases, the peptidase family S1. Tryptases are enzymatically active only as heparin-stabilized tetramers, and they are resistant to all known endogenous proteinase inhibitors. Several tryptase genes are clustered on chromosome 16p13.3. There is uncertainty regarding the number of genes in this cluster. Currently four functional genes - alpha I, beta I, beta II and gamma I - have been identified. And beta I has an allelic variant named alpha II, beta II has an allelic variant beta III, also gamma I has an allelic variant gamma II. Beta tryptases appear to be the main isoenzymes expressed in mast cells; whereas in basophils, alpha-tryptases predominant. This gene differs from other members of the tryptase gene family in that it has C-terminal hydrophobic domain, which may serve as a membrane anchor. Tryptases have been implicated as mediators in the pathogenesis of asthma and other allergic and inflammatory disorders. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||
| Type | Protein coding | ||||||||
| Genomic Location | Chromosome 16:1221651-1225257 | ||||||||
| Strand | Reverse strand | ||||||||
| Band | p13.3 | ||||||||
| Transcripts |
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| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||
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Species
Mus musculus
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Gene ID
Gene Order
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| Cross-References | |||||||||
| SwissProt | Q9NRR2 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 25823 | ||||||||
| UniGene | Hs.592076 | ||||||||
| RefSeq | NM_012467 XM_006720876 | ||||||||
| HUGO | HGNC:14134 | ||||||||
| OMIM | 609341 | ||||||||
| CCDS | CCDS10430 | ||||||||
| HPRD | |||||||||
| IMGT | |||||||||
| EMBL | AC120498 AE006466 AF175522 AF175759 AF191031 AF195508 AF223563 | ||||||||
| GenPept | AAF03695 AAF03697 AAF76457 AAF76458 AAG48852 AAK61269 | ||||||||
| RNA Seq Atlas | 25823 | ||||||||