Version 5.4
Mus musculus Gene: Csnk1a1
Summary
InnateDB Gene IDBG-152046.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Csnk1a1
Gene Name casein kinase 1, alpha 1
Synonyms 2610208K14Rik; 4632404G05Rik; 5430427P18Rik; CK1a; Csnk1a
Species Mus musculus
Ensembl Gene ENSMUSG00000024576
Encoded Proteins
IDBP-250053
casein kinase 1, alpha 1
IDBP-623173
casein kinase 1, alpha 1
IDBP-623176
casein kinase 1, alpha 1
IDBP-623179
casein kinase 1, alpha 1
IDBP-623181
casein kinase 1, alpha 1
IDBP-623188
casein kinase 1, alpha 1
IDBP-623190
casein kinase 1, alpha 1
IDBP-623192
casein kinase 1, alpha 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 18:61555274-61590061
Strand Forward strand
Band E1
Transcripts
ENSMUST00000115246 ENSMUSP00000110901
ENSMUST00000165123 ENSMUSP00000128871
ENSMUST00000165721 ENSMUSP00000132083
ENSMUST00000166990 ENSMUSP00000131687
ENSMUST00000163205 ENSMUSP00000127144
ENSMUST00000165381
ENSMUST00000170862 ENSMUSP00000127265
ENSMUST00000167187 ENSMUSP00000127463
ENSMUST00000164253 ENSMUSP00000129295
ENSMUST00000170482
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000902 cell morphogenesis
GO:0006468 protein phosphorylation
GO:0007067 mitotic nuclear division
GO:0016055 Wnt signaling pathway
Cellular Component
GO:0000777 condensed chromosome kinetochore
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005847 mRNA cleavage and polyadenylation specificity factor complex
GO:0016607 nuclear speck
GO:0030529 ribonucleoprotein complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_258066
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_214014
Signaling by Wnt pathway
REACT_269412
Hedgehog 'off' state pathway
REACT_218396
Beta-catenin phosphorylation cascade pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_203336
Degradation of beta-catenin by the destruction complex pathway
REACT_235529
AMER1 mutants destabilize the destruction complex pathway
REACT_231507
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_258576
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_230286
APC truncation mutants have impaired AXIN binding pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_241514
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_270923
Degradation of GLI2 by the proteasome pathway
REACT_216784
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_236203
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_234076
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_252458
AXIN missense mutants destabilize the destruction complex pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_268522
GLI3 is processed to GLI3R by the proteasome pathway
REACT_263691
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_248000
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_261276
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_254498
TCF7L2 mutants don't bind CTBP pathway
REACT_250714
truncations of AMER1 destabilize the destruction complex pathway
REACT_250064
Signaling by Hedgehog pathway
REACT_188257
Signal Transduction pathway
REACT_237096
truncated APC mutants destabilize the destruction complex pathway
REACT_260752
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
mmu04310
Wnt signaling pathway pathway
mmu04340
Hedgehog signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt Q8BK63
TrEMBL E9Q4G7
UniProt Splice Variant
Entrez Gene 93687
UniGene Mm.26908 Mm.472989 Mm.473442 Mm.486630
RefSeq NM_146087
OMIM
CCDS CCDS37838
HPRD
IMGT
MGI ID MGI:1934950
MGI Symbol Csnk1a1
EMBL AC153155 AK076070 AK078398 AK146873 BC002171 BC048081 X90945
GenPept AAH02171 AAH48081 BAC36161 BAC37255 BAE27496 CAA62440
RNA Seq Atlas 93687

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca