InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Csnk1a1

Summary

InnateDB Protein

IDBP-623173.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Csnk1a1

Protein Name

casein kinase 1, alpha 1

Synonyms

2610208K14Rik; 4632404G05Rik; 5430427P18Rik; CK1a; Csnk1a;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000128871

InnateDB Gene

IDBG-152046 (Csnk1a1)

Protein Structure

UniProt Annotation

Function

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates CTNNB1 at 'Ser-45'. May phosphorylate PER1 and PER2. May play a role in segregating chromosomes during mitosis. {ECO:0000269PubMed:21930935}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Chromosome, centromere, kinetochore {ECO:0000250}. Nucleus speckle {ECO:0000250}. Note=Localizes to the centrosome in interphase cells, and to kinetochore fibers during mitosis. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000902	cell morphogenesis
GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0016055	Wnt signaling pathway

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
GO:0016607	nuclear speck
GO:0030529	ribonucleoprotein complex

Protein Structure and Domains

PDB ID

MGI:1934950

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt