Version 5.4
Homo sapiens Gene: UCHL1
Summary
InnateDB Gene IDBG-15224.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UCHL1
Gene Name ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Synonyms HEL-117; NDGOA; PARK5; PGP 9.5; PGP9.5; PGP95; Uch-L1
Species Homo sapiens
Ensembl Gene ENSG00000154277
Encoded Proteins
IDBP-15230
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
IDBP-480131
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
IDBP-485072
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
IDBP-483193
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
IDBP-477161
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
IDBP-484305
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
IDBP-481886
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 23717208
Human papillomavirus exploits UCHL1 to suppress interferon, pro-inflammatory cytokines and chemokines production and to dampen NF-kB signalling.
Entrez Gene
Summary The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:41256413-41268455
Strand Forward strand
Band p13
Transcripts
ENST00000284440 ENSP00000284440
ENST00000381760
ENST00000514924 ENSP00000426634
ENST00000503431 ENSP00000422542
ENST00000512419 ENSP00000425714
ENST00000505232 ENSP00000423348
ENST00000504818
ENST00000508768 ENSP00000426895
ENST00000512788 ENSP00000423623
ENST00000472501
ENST00000514764
ENST00000510566
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 64 [view]
Protein-Protein 61 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0004221 ubiquitin thiolesterase activity
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008242 omega peptidase activity
GO:0016874 ligase activity
GO:0031694 alpha-2A adrenergic receptor binding
GO:0043130 ubiquitin binding
Biological Process
GO:0002931 response to ischemia
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007409 axonogenesis
GO:0007412 axon target recognition
GO:0007628 adult walking behavior
GO:0008219 cell death
GO:0008283 cell proliferation
GO:0016579 protein deubiquitination
GO:0019233 sensory perception of pain
GO:0019896 axon transport of mitochondrion
GO:0042755 eating behavior
GO:0043407 negative regulation of MAP kinase activity
GO:0045087 innate immune response (InnateDB)
GO:0048747 muscle fiber development
GO:0050905 neuromuscular process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030424 axon
GO:0043025 neuronal cell body
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029223
View Gene Order
ENSBTAG00000005078
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05012
Parkinson's disease pathway
INOH
PID NCI
alphasynuclein_pathway
Alpha-synuclein signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_004181
HUGO
OMIM
CCDS CCDS3462
HPRD 01877
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca