InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Uchl1

Summary

InnateDB Gene

IDBG-167601.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Uchl1

Gene Name

ubiquitin carboxy-terminal hydrolase L1

Synonyms

AW822034; C88048; gad; PGP 9.5; PGP9.5; R75593; UCH-L1; UCHL-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000029223

Encoded Proteins

IDBP-167603

ubiquitin carboxy-terminal hydrolase L1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 23717208

[Homo sapiens] Human papillomavirus exploits UCHL1 to suppress interferon, pro-inflammatory cytokines and chemokines production and to dampen NF-kB signalling.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154277:
The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:66676098-66687231

Strand

Forward strand

Band

C3.1

Transcripts

ENSMUST00000031131	ENSMUSP00000031131
ENSMUST00000177194
ENSMUST00000176015

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 51 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	51 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0004221	ubiquitin thiolesterase activity
GO:0004843	ubiquitin-specific protease activity
GO:0005515	protein binding
GO:0008242	omega peptidase activity
GO:0016874	ligase activity
GO:0031694	alpha-2A adrenergic receptor binding
GO:0043130	ubiquitin binding

Biological Process

GO:0002931	response to ischemia
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0007409	axonogenesis
GO:0007412	axon target recognition
GO:0007628	adult walking behavior
GO:0008283	cell proliferation
GO:0016579	protein deubiquitination
GO:0019233	sensory perception of pain
GO:0019896	axon transport of mitochondrion
GO:0042755	eating behavior
GO:0043407	negative regulation of MAP kinase activity
GO:0048747	muscle fiber development
GO:0050905	neuromuscular process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030424	axon
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000154277

View Gene Order

ENSBTAG00000005078

Not yet available

Pathways

NETPATH

REACTOME

KEGG

mmu05012

Parkinson's disease pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

hsa05012

Parkinson's disease pathway

INOH

PID NCI

alphasynuclein_pathway

Alpha-synuclein signaling

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.29807 Mm.408572

RefSeq

NM_011670

OMIM

CCDS

CCDS19315

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas