InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pvrl2

Summary

InnateDB Gene

IDBG-152351.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pvrl2

Gene Name

poliovirus receptor-related 2

Synonyms

AI325026; AI987993; Cd112; MPH; nectin-2; Pvr; Pvs

Species

Mus musculus

Ensembl Gene

ENSMUSG00000062300

Encoded Proteins

IDBP-152353

poliovirus receptor-related 2

IDBP-264510

poliovirus receptor-related 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000130202:
This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:19716644-19749573

Strand

Reverse strand

Band

Transcripts

ENSMUST00000075447	ENSMUSP00000074898
ENSMUST00000108450	ENSMUSP00000104089

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001675	acrosome assembly
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002891	positive regulation of immunoglobulin mediated immune response
GO:0007010	cytoskeleton organization
GO:0007156	homophilic cell adhesion
GO:0007286	spermatid development
GO:0007289	spermatid nucleus differentiation
GO:0009566	fertilization
GO:0019064	fusion of virus membrane with host plasma membrane
GO:0030382	sperm mitochondrion organization
GO:0032990	cell part morphogenesis
GO:0033005	positive regulation of mast cell activation
GO:0042271	susceptibility to natural killer cell mediated cytotoxicity
GO:0044406	adhesion of symbiont to host
GO:0044782	cilium organization
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0046814	virion attachment, binding of host cell surface coreceptor
GO:0051654	establishment of mitochondrion localization
GO:0060370	susceptibility to T cell mediated cytotoxicity

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005915	zonula adherens
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome