InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pvrl2

Summary

InnateDB Protein

IDBP-152353.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pvrl2

Protein Name

poliovirus receptor-related 2

Synonyms

AI325026; AI987993; Cd112; MPH; nectin-2; Pvr; Pvs;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000074898

InnateDB Gene

IDBG-152351 (Pvrl2)

Protein Structure

UniProt Annotation

Function

Probable cell adhesion protein.

Subcellular Localization

Cell membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Brain, spinal cord, spleen, kidney, heart and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0001675	acrosome assembly
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0002891	positive regulation of immunoglobulin mediated immune response
GO:0007010	cytoskeleton organization
GO:0007156	homophilic cell adhesion
GO:0007286	spermatid development
GO:0007289	spermatid nucleus differentiation
GO:0009566	fertilization
GO:0019064	fusion of virus membrane with host plasma membrane
GO:0030382	sperm mitochondrion organization
GO:0032990	cell part morphogenesis
GO:0033005	positive regulation of mast cell activation
GO:0042271	susceptibility to natural killer cell mediated cytotoxicity
GO:0044406	adhesion of symbiont to host
GO:0044782	cilium organization
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0046814	virion attachment, binding of host cell surface coreceptor
GO:0051654	establishment of mitochondrion localization
GO:0060370	susceptibility to T cell mediated cytotoxicity

Cellular Component

GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005915	zonula adherens
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:97822

InterPro

IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR013162 CD80-like, immunoglobulin C2-set

PFAM

PF07686
PF08205

PRINTS

PIRSF

SMART

SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32507