Version 5.4
Mus musculus Gene: Bcl3
Summary
InnateDB Gene IDBG-152576.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Bcl3
Gene Name B cell leukemia/lymphoma 3
Synonyms AI528691; Bcl-3
Species Mus musculus
Ensembl Gene ENSMUSG00000053175
Encoded Proteins
IDBP-401407
B-cell leukemia/lymphoma 3
IDBP-531681
B-cell leukemia/lymphoma 3
IDBP-535353
B-cell leukemia/lymphoma 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21228348
Bcl3 is critically involved in lung defense against Gram-negative bacteria Klebsiella pneumoniae, modulating functions of several cells to facilitate efficient clearance of bacteria. Loss of Bcl3 incurred dramatic cytokine imbalance in the lungs, failure to clear bacteria and increased susceptibility to K. pneumoniae pneumonia.
InnateDB Annotation from Orthologs
Summary
PMID 21228348
[Homo sapiens] BCL3 is critically involved in lung defence against Gram-negative bacteria Klebsiella pneumoniae, modulating functions of several cells to facilitate efficient clearance of bacteria. Loss of BCL3 incurred dramatic cytokine imbalance in the lungs, failure to clear bacteria and increased susceptibility to K. pneumoniae pneumonia. (Demonstrated in murine model)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000069399:
This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:19808462-19822770
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000120537 ENSMUSP00000113851
ENSMUST00000135609 ENSMUSP00000117754
ENSMUST00000152768
ENSMUST00000123375
ENSMUST00000141996
ENSMUST00000139680 ENSMUSP00000116129
ENSMUST00000146194
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 5 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 44 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0002268 follicular dendritic cell differentiation
GO:0002315 marginal zone B cell differentiation
GO:0002455 humoral immune response mediated by circulating immunoglobulin
GO:0002467 germinal center formation
GO:0006351 transcription, DNA-templated
GO:0006974 cellular response to DNA damage stimulus
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0009615 response to virus
GO:0010225 response to UV-C
GO:0019730 antimicrobial humoral response
GO:0030198 extracellular matrix organization
GO:0030330 DNA damage response, signal transduction by p53 class mediator
GO:0032729 positive regulation of interferon-gamma production
GO:0042088 T-helper 1 type immune response
GO:0042345 regulation of NF-kappaB import into nucleus
GO:0042536 negative regulation of tumor necrosis factor biosynthetic process
GO:0042742 defense response to bacterium
GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0042832 defense response to protozoan
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0045064 T-helper 2 cell differentiation
GO:0045082 positive regulation of interleukin-10 biosynthetic process
GO:0045087 innate immune response (InnateDB)
GO:0045415 negative regulation of interleukin-8 biosynthetic process
GO:0045727 positive regulation of translation
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048536 spleen development
GO:0051101 regulation of DNA binding
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0032996 Bcl3-Bcl10 complex
GO:0033257 Bcl3/NF-kappaB2 complex
GO:0043234 protein complex
GO:0045171 intercellular bridge
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000069399
View Gene Order
ENSBTAG00000009493
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
nfkappabatypicalpathway
Atypical NF-kappaB pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.404119 Mm.439658
RefSeq NM_033601
OMIM
CCDS CCDS20914
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca