InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Bcl3

Summary

InnateDB Protein

IDBP-535353.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Bcl3

Protein Name

B-cell leukemia/lymphoma 3

Synonyms

AI528691; Bcl-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000116129

InnateDB Gene

IDBG-152576 (Bcl3)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 44 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	44 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding

Biological Process

GO:0002268	follicular dendritic cell differentiation
GO:0002315	marginal zone B cell differentiation
GO:0002455	humoral immune response mediated by circulating immunoglobulin
GO:0002467	germinal center formation
GO:0019730	antimicrobial humoral response
GO:0030198	extracellular matrix organization
GO:0032729	positive regulation of interferon-gamma production
GO:0042088	T-helper 1 type immune response
GO:0042536	negative regulation of tumor necrosis factor biosynthetic process
GO:0042742	defense response to bacterium
GO:0042832	defense response to protozoan
GO:0043066	negative regulation of apoptotic process
GO:0045064	T-helper 2 cell differentiation
GO:0045082	positive regulation of interleukin-10 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048536	spleen development

Cellular Component

Protein Structure and Domains

PDB ID

MGI:88140

InterPro

IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF11929
PF12796

PRINTS

PR01415

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

D3Z6Z2

UniProt Splice Variant

Entrez Gene

12051

UniGene

Mm.439658

RefSeq

MGI ID

MGI Symbol

Bcl3

OMIM

CCDS

HPRD

IMGT

EMBL

AC149085 AC149282

GenPept