InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Adrb2

Summary

InnateDB Gene

IDBG-152615.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Adrb2

Gene Name

adrenergic receptor, beta 2

Synonyms

Adrb-2; Badm; Gpcr7

Species

Mus musculus

Ensembl Gene

ENSMUSG00000045730

Encoded Proteins

IDBP-152617

adrenergic receptor, beta 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21683614

Activation of Adrb2 on Nod2/Tlr2-stimulated dendritic cells biases the cell priming ability towards an Th17 immune response.

InnateDB Annotation from Orthologs

Summary

PMID 21683614

[Homo sapiens] Activation of ADRB2 on NOD2/TLR2-stimulated dendritic cells biases the cell priming ability towards an Th17 immune response. (Demonstrated in murine model)

Entrez Gene

Summary

This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 adrenergic receptor which is activated by catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3\'-5\'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:62177817-62179959

Strand

Reverse strand

Band

Transcripts

ENSMUST00000053640

ENSMUSP00000062256

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 36 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	36 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0004941	beta2-adrenergic receptor activity
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0015459	potassium channel regulator activity
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0051380	norepinephrine binding

Biological Process

GO:0001993	regulation of systemic arterial blood pressure by norepinephrine-epinephrine
GO:0002024	diet induced thermogenesis
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0002028	regulation of sodium ion transport
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0006898	receptor-mediated endocytosis
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0009409	response to cold
GO:0030501	positive regulation of bone mineralization
GO:0031398	positive regulation of protein ubiquitination
GO:0031649	heat generation
GO:0040015	negative regulation of multicellular organism growth
GO:0042312	regulation of vasodilation
GO:0043410	positive regulation of MAPK cascade
GO:0045087	innate immune response (InnateDB)
GO:0045453	bone resorption
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045986	negative regulation of smooth muscle contraction
GO:0050873	brown fat cell differentiation
GO:0071875	adrenergic receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043235	receptor complex