InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: ADRB2

Summary

InnateDB Gene

IDBG-648668.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADRB2

Gene Name

Beta-2 adrenergic receptor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002144

Encoded Proteins

IDBP-701391

Beta-2 adrenergic receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21683614

[Homo sapiens] Activation of ADRB2 on NOD2/TLR2-stimulated dendritic cells biases the cell priming ability towards an Th17 immune response. (Demonstrated in murine model)

PMID 21683614

[Mus musculus] Activation of Adrb2 on Nod2/Tlr2-stimulated dendritic cells biases the cell priming ability towards an Th17 immune response.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000169252:
This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:62229186-62230442

Strand

Forward strand

Band

Transcripts

ENSBTAT00000002779

ENSBTAP00000002779

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 37 interaction(s) predicted by orthology.

Predicted by orthology
Total	37 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0004930	G-protein coupled receptor activity
GO:0004935	adrenergic receptor activity
GO:0004941	beta2-adrenergic receptor activity
GO:0005515	protein binding
GO:0008179	adenylate cyclase binding
GO:0015459	potassium channel regulator activity
GO:0019899	enzyme binding
GO:0042803	protein homodimerization activity
GO:0051380	norepinephrine binding

Biological Process

GO:0001993	regulation of systemic arterial blood pressure by norepinephrine-epinephrine
GO:0002024	diet induced thermogenesis
GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
GO:0002028	regulation of sodium ion transport
GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0006898	receptor-mediated endocytosis
GO:0006940	regulation of smooth muscle contraction
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007190	activation of adenylate cyclase activity
GO:0009409	response to cold
GO:0030501	positive regulation of bone mineralization
GO:0031398	positive regulation of protein ubiquitination
GO:0031649	heat generation
GO:0040015	negative regulation of multicellular organism growth
GO:0042312	regulation of vasodilation
GO:0043410	positive regulation of MAPK cascade
GO:0045453	bone resorption
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045986	negative regulation of smooth muscle contraction
GO:0050873	brown fat cell differentiation
GO:0071875	adrenergic receptor signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016324	apical plasma membrane
GO:0043235	receptor complex