Version 5.4
Mus musculus Gene: Arg2
Summary
InnateDB Gene IDBG-152630.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Arg2
Gene Name arginase type II
Synonyms AII; AU022422
Species Mus musculus
Ensembl Gene ENSMUSG00000021125
Encoded Proteins
IDBP-152632
arginase type II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000081181:
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:79130777-79156301
Strand Forward strand
Band C3
Transcripts
ENSMUST00000021550 ENSMUSP00000021550
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004053 arginase activity
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0046872 metal ion binding
Biological Process
GO:0000050 urea cycle
GO:0001657 ureteric bud development
GO:0006525 arginine metabolic process
GO:0006941 striated muscle contraction
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000081181
View Gene Order
ENSBTAG00000001945
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_246679
Urea cycle pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
KEGG
mmu00330
Arginine and proline metabolism pathway
mmu05146
Amoebiasis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_847
Urea cycle pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa05146
Amoebiasis pathway
INOH
INOH website
Arginine Proline metabolism pathway
PID NCI
Cross-References
SwissProt O08691
TrEMBL
UniProt Splice Variant
Entrez Gene 11847
UniGene Mm.3506
RefSeq NM_009705
OMIM
CCDS CCDS26007
HPRD
IMGT
MGI ID MGI:1330806
MGI Symbol Arg2
EMBL AF032466 AF044680 AF045959 AF045960 AF045961 AF045962 AF045963 AF045964 AF045965 U90886
GenPept AAB86959 AAC22548 AAC78460
RNA Seq Atlas 11847

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca