InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARG2

Summary

InnateDB Gene

IDBG-9946.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARG2

Gene Name

arginase, type II

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000081181

Encoded Proteins

IDBP-9948

arginase, type II

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:67619798-67651720

Strand

Forward strand

Band

q24.1

Transcripts

ENST00000261783	ENSP00000261783
ENST00000557120
ENST00000556491
ENST00000557319

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	2 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004053	arginase activity
GO:0046872	metal ion binding

Biological Process

GO:0000050	urea cycle
GO:0001657	ureteric bud development
GO:0006525	arginine metabolic process
GO:0006809	nitric oxide biosynthetic process
GO:0006941	striated muscle contraction
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021125

View Gene Order

ENSBTAG00000001945

Not yet available

Pathways

NETPATH

REACTOME

REACT_847

Urea cycle pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00330

Arginine and proline metabolism pathway

hsa05146

Amoebiasis pathway

INOH

INOH website

Arginine Proline metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.226007

RefSeq

NM_001172

HUGO

OMIM

CCDS

CCDS9785

HPRD

00143

IMGT

EMBL

GenPept

RNA Seq Atlas