Version 5.4
Mus musculus Gene: Msln
Summary
InnateDB Gene IDBG-152832.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Msln
Gene Name mesothelin
Synonyms MPF
Species Mus musculus
Ensembl Gene ENSMUSG00000063011
Encoded Proteins
IDBP-152834
mesothelin
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000102854:
This gene encodes a precursor protein that is cleaved into two products, megakaryocyte potentiating factor and mesothelin. Megakaryocyte potentiation factor functions as a cytokine that can stimulate colony formation in bone marrow megakaryocytes. Mesothelian is a glycosylphosphatidylinositol-anchored cell-surface protein that may function as a cell adhesion protein. This protein is overexpressed in epithelial mesotheliomas, ovarian cancers and in specific squamous cell carcinomas. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:25748614-25754327
Strand Reverse strand
Band A3.3
Transcripts
ENSMUST00000075884 ENSMUSP00000075279
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0031016 pancreas development
Cellular Component
GO:0005615 extracellular space
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0031225 anchored component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000102854
View Gene Order
ENSBTAG00000000177
Not yet available
Cross-References
SwissProt Q61468
TrEMBL
UniProt Splice Variant
Entrez Gene 56047
UniGene Mm.17510
RefSeq NM_018857 XM_006524649 XM_006524650
OMIM
CCDS CCDS28526
HPRD
IMGT
MGI ID MGI:1888992
MGI Symbol Msln
EMBL AK144391 AK146799 BC023753 D86370
GenPept AAH23753 BAA13077 BAE25864 BAE27441
RNA Seq Atlas 56047

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca