InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Stat4

Summary

InnateDB Gene

IDBG-152917.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Stat4

Gene Name

signal transducer and activator of transcription 4

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000062939

Encoded Proteins

IDBP-152919

signal transducer and activator of transcription 4

IDBP-627043

signal transducer and activator of transcription 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 15356157

Stat4 is required for the generation of an effective innate host defense against bacterial pathogens of the lung.

PMID 24285835

Ity14 (Immunity to Typhimurium locus 14) mice with a mutation in Stat4 have an increased innate susceptibility following sublethal invasive S. Typhimurium challenge.

InnateDB Annotation from Orthologs

Summary

PMID 17971840

[Homo sapiens] STAT4 is a transcription factor that mediates IL12 cytokine signalling, and as a member of the STAT protein family, STAT4 have significant impact on innate immunity during sepsis.

PMID 14704793

[Homo sapiens] STAT4 relies on the phosphorylation of it's N-domains to form STAT4 tetramer in response to cytokine-induced activation.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138378:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:51987148-52107189

Strand

Forward strand

Band

C1.1

Transcripts

ENSMUST00000027277	ENSMUSP00000027277
ENSMUST00000168302	ENSMUSP00000130713
ENSMUST00000187053
ENSMUST00000187554

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 360 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	360 [view]
Protein-Protein	11 [view]
Protein-DNA	349 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0008283	cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071310	cellular response to organic substance