InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STAT4

Summary

InnateDB Gene

IDBG-77625.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAT4

Gene Name

signal transducer and activator of transcription 4

Synonyms

SLEB11

Species

Homo sapiens

Ensembl Gene

ENSG00000138378

Encoded Proteins

IDBP-77627

signal transducer and activator of transcription 4

IDBP-245896

signal transducer and activator of transcription 4

IDBP-293284

signal transducer and activator of transcription 4

IDBP-388078

signal transducer and activator of transcription 4

IDBP-388079

signal transducer and activator of transcription 4

IDBP-388080

signal transducer and activator of transcription 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 17971840

STAT4 is a transcription factor that mediates IL12 cytokine signalling, and as a member of the STAT protein family, STAT4 have significant impact on innate immunity during sepsis.

PMID 14704793

STAT4 relies on the phosphorylation of it's N-domains to form STAT4 tetramer in response to cytokine-induced activation.

InnateDB Annotation from Orthologs

Summary

PMID 15356157

[Mus musculus] Stat4 is required for the generation of an effective innate host defense against bacterial pathogens of the lung.

PMID 24285835

[Mus musculus] Ity14 (Immunity to Typhimurium locus 14) mice with a mutation in Stat4 have an increased innate susceptibility following sublethal invasive S. Typhimurium challenge.

Entrez Gene

Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:191029576-191151596

Strand

Reverse strand

Band

q32.3

Transcripts

ENST00000358470	ENSP00000351255
ENST00000392320	ENSP00000376134
ENST00000409995	ENSP00000386288
ENST00000413064	ENSP00000403238
ENST00000450994	ENSP00000412397
ENST00000432798	ENSP00000414322
ENST00000463951
ENST00000495849
ENST00000470708
ENST00000495326

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	12 [view]
Protein-DNA	9 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007259	JAK-STAT cascade
GO:0008283	cell proliferation
GO:0019221	cytokine-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0071310	cellular response to organic substance