InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ero1l

Summary

InnateDB Gene

IDBG-152980.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ero1l

Gene Name

ERO1-like (S. cerevisiae)

Synonyms

ERO1-L

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021831

Encoded Proteins

IDBP-152982

ERO1-like (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the endoplasmic reticulum oxidoreductin family. The encoded protein is localized to the endoplasmic reticulum and promotes the formation of disulfide bonds by oxidizing protein disulfide isomerase. This gene may play a role in endoplasmic reticulum stress-induced apoptosis and the cellular response to hypoxia. [provided by RefSeq, Feb 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:45283092-45318572

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022378

ENSMUSP00000022378

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0005515	protein binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0016491	oxidoreductase activity
GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

Biological Process

GO:0006457	protein folding
GO:0019471	4-hydroxyproline metabolic process
GO:0022417	protein maturation by protein folding
GO:0030198	extracellular matrix organization
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0034976	response to endoplasmic reticulum stress
GO:0045454	cell redox homeostasis
GO:0050873	brown fat cell differentiation
GO:0051085	chaperone mediated protein folding requiring cofactor
GO:0051209	release of sequestered calcium ion into cytosol
GO:0055114	oxidation-reduction process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress