Version 5.4
Homo sapiens Gene: ERO1L
Summary
InnateDB Gene IDBG-6806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ERO1L
Gene Name ERO1-like (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197930
Encoded Proteins
IDBP-239035
ERO1-like (S. cerevisiae)
IDBP-583547
ERO1-like (S. cerevisiae)
IDBP-587091
ERO1-like (S. cerevisiae)
IDBP-586574
ERO1-like (S. cerevisiae)
IDBP-590960
ERO1-like (S. cerevisiae)
IDBP-586537
ERO1-like (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 14:52639916-52695900
Strand Reverse strand
Band q22.1
Transcripts
ENST00000395686 ENSP00000379042
ENST00000553714
ENST00000554019 ENSP00000451204
ENST00000556039 ENSP00000452020
ENST00000555069
ENST00000556358 ENSP00000450655
ENST00000556769
ENST00000554251 ENSP00000452269
ENST00000557178
ENST00000556223 ENSP00000452093
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 21 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003756 protein disulfide isomerase activity
GO:0005515 protein binding
GO:0015035 protein disulfide oxidoreductase activity
GO:0016491 oxidoreductase activity
GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
Biological Process
GO:0006457 protein folding
GO:0006464 cellular protein modification process
GO:0009266 response to temperature stimulus
GO:0019471 4-hydroxyproline metabolic process
GO:0022417 protein maturation by protein folding
GO:0030198 extracellular matrix organization
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0034976 response to endoplasmic reticulum stress
GO:0044267 cellular protein metabolic process
GO:0045454 cell redox homeostasis
GO:0050873 brown fat cell differentiation
GO:0051085 chaperone mediated protein folding requiring cofactor
GO:0051209 release of sequestered calcium ion into cytosol
GO:0055114 oxidation-reduction process
GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021831
View Gene Order
ENSBTAG00000015716
Not yet available
Pathways
NETPATH
REACTOME
REACT_15550
Insulin processing pathway
REACT_120956
Cellular responses to stress pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
hsa05110
Vibrio cholerae infection pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL G3V503
UniProt Splice Variant
Entrez Gene 30001
UniGene Hs.525339 Hs.592304 Hs.602956 Hs.624444
RefSeq NM_014584
HUGO HGNC:13280
OMIM 615435
CCDS CCDS9709
HPRD 13278
IMGT
EMBL AL133453
GenPept
RNA Seq Atlas 30001

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca