Version 5.4
Mus musculus Gene: Hpgds
Summary
InnateDB Gene IDBG-153041.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hpgds
Gene Name hematopoietic prostaglandin D synthase
Synonyms H-PGDS; Ptgds2
Species Mus musculus
Ensembl Gene ENSMUSG00000029919
Encoded Proteins
IDBP-153043
hematopoietic prostaglandin D synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000163106:
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:65117293-65144908
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000031982 ENSMUSP00000031982
ENSMUST00000170252
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004364 glutathione transferase activity
GO:0004667 prostaglandin-D synthase activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001516 prostaglandin biosynthetic process
GO:0006693 prostaglandin metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000163106
View Gene Order
ENSBTAG00000017073
Not yet available
Pathways
NETPATH
REACTOME
REACT_243247
Phase II conjugation pathway
REACT_188937
Metabolism pathway
REACT_232291
Metabolism of lipids and lipoproteins pathway
REACT_215316
Glutathione conjugation pathway
REACT_232343
Biological oxidations pathway
REACT_188623
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
REACT_188625
Arachidonic acid metabolism pathway
KEGG
mmu00590
Arachidonic acid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150149
Synthesis of Prostaglandins (PG) and Thromboxanes (TX) pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_6926
Glutathione conjugation pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_019455 XM_006506398
OMIM
CCDS CCDS20205
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca