InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hpgds

Summary

InnateDB Protein

IDBP-153043.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hpgds

Protein Name

hematopoietic prostaglandin D synthase

Synonyms

H-PGDS; Ptgds2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031982

InnateDB Gene

IDBG-153041 (Hpgds)

Protein Structure

UniProt Annotation

Function

Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity. {ECO:0000269PubMed:10824118, ECO:0000269PubMed:16547010}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Expressed in skin and oviduct. {ECO:0000269PubMed:10824118}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004364	glutathione transferase activity
GO:0004667	prostaglandin-D synthase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001516	prostaglandin biosynthetic process
GO:0006693	prostaglandin metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:1859384

InterPro

IPR004045 Glutathione S-transferase, N-terminal
IPR004046 Glutathione S-transferase, C-terminal
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold

PFAM