Version 5.4
Mus musculus Gene: Fam38b
Summary
InnateDB Gene IDBG-153173.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Fam38b
Gene Name family with sequence similarity 38, member B
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000041482
Encoded Proteins
IDBP-153175
family with sequence similarity 38, member B
IDBP-153328
family with sequence similarity 38, member B
IDBP-539625
family with sequence similarity 38, member B
IDBP-789328
piezo-type mechanosensitive ion channel component 2
IDBP-789330
piezo-type mechanosensitive ion channel component 2
IDBP-789331
piezo-type mechanosensitive ion channel component 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000154864:
Piezos are large transmembrane proteins conserved among various species, all having between 24 and 36 predicted transmembrane domains. 'Piezo' comes from the Greek 'piesi,' meaning 'pressure.' The PIEZO2 protein has a role in rapidly adapting mechanically activated (MA) currents in somatosensory neurons (Coste et al., 2010 [PubMed 20813920]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:63010213-63387183
Strand Reverse strand
Band E1
Transcripts
ENSMUST00000047480 ENSMUSP00000040019
ENSMUST00000046860 ENSMUSP00000036099
ENSMUST00000137141 ENSMUSP00000117107
ENSMUST00000132576
ENSMUST00000123322
ENSMUST00000183217 ENSMUSP00000138758
ENSMUST00000182233 ENSMUSP00000138170
ENSMUST00000182166 ENSMUSP00000138754
ENSMUST00000182177
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005261 cation channel activity
GO:0008381 mechanically-gated ion channel activity
Biological Process
GO:0006812 cation transport
GO:0009612 response to mechanical stimulus
GO:0034220 ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0050974 detection of mechanical stimulus involved in sensory perception
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000154864
View Gene Order
ENSBTAG00000011171
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 667742
UniGene Mm.158720
RefSeq NM_001039485 XM_006526172 XM_006526173
OMIM
CCDS
HPRD
IMGT
MGI ID MGI:1918781
MGI Symbol Piezo2
EMBL
GenPept
RNA Seq Atlas 667742

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca