InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Etfdh

Summary

InnateDB Gene

IDBG-153179.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Etfdh

Gene Name

electron transferring flavoprotein, dehydrogenase

Synonyms

0610010I20Rik; AV001013

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027809

Encoded Proteins

IDBP-153181

electron transferring flavoprotein, dehydrogenase

IDBP-401300

electron transferring flavoprotein, dehydrogenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000171503:
Electron-transferring-flavoprotein dehydrogenase in the inner mitochondrial membrane accepts electrons from electron-transfer flavoprotein which is located in the mitochondrial matrix and reduces ubiquinone in the mitochondrial membrane. The protein is synthesized as a 67-kDa precursor which is targeted to mitochondria and processed in a single step to a 64-kDa mature form located in the mitochondrial membrane. Deficiency in electron-transferring-flavoprotein dehydrogenase have been demonstrated in some patients with type II glutaricacidemia. [provided by RefSeq, Jul 2008]
This gene encodes a component of the electron-transfer system in mitochondria and is essential for electron transfer from a number of mitochondrial flavin-containing dehydrogenases to the main respiratory chain. Mutations in this gene are associated with glutaric acidemia. Alternatively spliced transcript variants that encode distinct isoforms have been observed. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:79603788-79628863

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029386	ENSMUSP00000029386
ENSMUST00000120992	ENSMUSP00000113888
ENSMUST00000135058
ENSMUST00000153039
ENSMUST00000149511
ENSMUST00000126809

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004174	electron-transferring-flavoprotein dehydrogenase activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0043783	oxidoreductase activity, oxidizing metal ions with flavin as acceptor
GO:0046872	metal ion binding
GO:0048038	quinone binding
GO:0048039	ubiquinone binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006979	response to oxidative stress
GO:0022900	electron transport chain
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0017133	mitochondrial electron transfer flavoprotein complex
GO:0031305	integral component of mitochondrial inner membrane
GO:0031966	mitochondrial membrane