InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Etfdh

Summary

InnateDB Protein

IDBP-153181.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Etfdh

Protein Name

electron transferring flavoprotein, dehydrogenase

Synonyms

0610010I20Rik; AV001013;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029386

InnateDB Gene

IDBG-153179 (Etfdh)

Protein Structure

UniProt Annotation

Function

Accepts electrons from ETF and reduces ubiquinone. {ECO:0000250}.

Subcellular Localization

Mitochondrion inner membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004174	electron-transferring-flavoprotein dehydrogenase activity
GO:0009055	electron carrier activity
GO:0016491	oxidoreductase activity
GO:0043783	oxidoreductase activity, oxidizing metal ions with flavin as acceptor
GO:0046872	metal ion binding
GO:0048038	quinone binding
GO:0048039	ubiquinone binding
GO:0051539	4 iron, 4 sulfur cluster binding

Biological Process

GO:0006979	response to oxidative stress
GO:0022900	electron transport chain
GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0017133	mitochondrial electron transfer flavoprotein complex
GO:0031305	integral component of mitochondrial inner membrane
GO:0031966	mitochondrial membrane

Protein Structure and Domains

PDB ID

MGI:106100

InterPro

IPR000103 Pyridine nucleotide-disulphide oxidoreductase, class-II
IPR003953 FAD binding domain
IPR007859 Electron transfer flavoprotein-ubiquinone oxidoreductase
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00890
PF05187
PF07992

PRINTS

PR00469

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q921G7