InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Tdo2

Summary

InnateDB Gene

IDBG-153973.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tdo2

Gene Name

tryptophan 2,3-dioxygenase

Synonyms

AA407491; chky; TDO; TO

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028011

Encoded Proteins

IDBP-153975

tryptophan 2,3-dioxygenase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151790:
This gene encodes a heme enzyme that plays a critical role in tryptophan metabolism by catalyzing the first and rate-limiting step of the kynurenine pathway. Increased activity of the encoded protein and subsequent kynurenine production may also play a role in cancer through the suppression of antitumor immune responses, and single nucleotide polymorphisms in this gene may be associated with autism. [provided by RefSeq, Feb 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:81957090-81975750

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029645	ENSMUSP00000029645
ENSMUST00000151089
ENSMUST00000137974

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004833	tryptophan 2,3-dioxygenase activity
GO:0016597	amino acid binding
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006568	tryptophan metabolic process
GO:0019441	tryptophan catabolic process to kynurenine
GO:0019442	tryptophan catabolic process to acetyl-CoA
GO:0055114	oxidation-reduction process