InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tdo2

Summary

InnateDB Protein

IDBP-153975.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tdo2

Protein Name

tryptophan 2,3-dioxygenase

Synonyms

AA407491; chky; TDO; TO;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029645

InnateDB Gene

IDBG-153973 (Tdo2)

Protein Structure

UniProt Annotation

Function

Incorporates oxygen into the indole moiety of tryptophan. Has a broad specificity towards tryptamine and derivatives including D- and L-tryptophan, 5-hydroxytryptophan and serotonin (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004833	tryptophan 2,3-dioxygenase activity
GO:0016597	amino acid binding
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006568	tryptophan metabolic process
GO:0019441	tryptophan catabolic process to kynurenine
GO:0019442	tryptophan catabolic process to acetyl-CoA
GO:0055114	oxidation-reduction process