Version 5.4
Mus musculus Gene: Il23r
Summary
InnateDB Gene IDBG-154001.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Il23r
Gene Name interleukin 23 receptor
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000049093
Encoded Proteins
IDBP-401172
interleukin 23 receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162594:
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:67422932-67491855
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000118364 ENSMUSP00000113342
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 0
Protein-DNA 6 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005143 interleukin-12 receptor binding
GO:0005515 protein binding
GO:0042019 interleukin-23 binding
GO:0042020 interleukin-23 receptor activity
Biological Process
GO:0002443 leukocyte mediated immunity
GO:0006954 inflammatory response
GO:0007259 JAK-STAT cascade
GO:0019221 cytokine-mediated signaling pathway
GO:0032496 response to lipopolysaccharide
GO:0032693 negative regulation of interleukin-10 production
GO:0032729 positive regulation of interferon-gamma production
GO:0032735 positive regulation of interleukin-12 production
GO:0034341 response to interferon-gamma
GO:0038155 interleukin-23-mediated signaling pathway
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0043235 receptor complex
GO:0072536 interleukin-23 receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000162594
View Gene Order
ENSBTAG00000014983
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04060
Cytokine-cytokine receptor interaction pathway
mmu04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04060
Cytokine-cytokine receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
il23pathway
IL23-mediated signaling events
Cross-References
SwissProt Q8K4B4
TrEMBL G5E8U4
UniProt Splice Variant
Entrez Gene 209590
UniGene Mm.221227
RefSeq NM_144548
OMIM
CCDS CCDS39503
HPRD
IMGT
MGI ID MGI:2181693
MGI Symbol Il23r
EMBL AC124758 AC159129 AF461423 BC112425 CH466523
GenPept AAI12426 AAM44230 EDK98806
RNA Seq Atlas 209590

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca