InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Il23r

Summary

InnateDB Protein

IDBP-401172.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Il23r

Protein Name

interleukin 23 receptor

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000113342

InnateDB Gene

IDBG-154001 (Il23r)

Protein Structure

UniProt Annotation

Function

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed by Th1, Th2 and dendritic cells. {ECO:0000269PubMed:12023369}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	0
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005143	interleukin-12 receptor binding
GO:0005515	protein binding
GO:0042019	interleukin-23 binding
GO:0042020	interleukin-23 receptor activity

Biological Process

GO:0002443	leukocyte mediated immunity
GO:0006954	inflammatory response
GO:0007259	JAK-STAT cascade
GO:0019221	cytokine-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0032693	negative regulation of interleukin-10 production
GO:0032729	positive regulation of interferon-gamma production
GO:0032735	positive regulation of interleukin-12 production
GO:0034341	response to interferon-gamma
GO:0038155	interleukin-23-mediated signaling pathway