InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Avpr2

Summary

InnateDB Gene

IDBG-154140.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Avpr2

Gene Name

arginine vasopressin receptor 2

Synonyms

ADHR; DI1; DIR; ND1; V2R; VPV2R

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031390

Encoded Proteins

IDBP-154142

arginine vasopressin receptor 2

IDBP-154144

arginine vasopressin receptor 2

IDBP-251860

arginine vasopressin receptor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the G-protein coupled receptor 1 family and the vasopressin/oxytocin receptor subfamily. The encoded protein is an arginine vasopressin receptor which, when stimulated, activates the Gs protein/adenylyl cyclase signaling cascade and is involved in water and electrolyte homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:73892102-73895502

Strand

Forward strand

Band

A7.3

Transcripts

ENSMUST00000101470	ENSMUSP00000099011
ENSMUST00000033765	ENSMUSP00000033765
ENSMUST00000114395	ENSMUSP00000110037
ENSMUST00000131088

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005000	vasopressin receptor activity
GO:0005515	protein binding

Biological Process

GO:0003084	positive regulation of systemic arterial blood pressure
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0021537	telencephalon development
GO:0032609	interferon-gamma production
GO:0034097	response to cytokine
GO:0035811	negative regulation of urine volume
GO:0035814	negative regulation of renal sodium excretion
GO:0045777	positive regulation of blood pressure