InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Avpr2

Summary

InnateDB Protein

IDBP-154144.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Avpr2

Protein Name

arginine vasopressin receptor 2

Synonyms

ADHR; DI1; DIR; ND1; V2R; VPV2R;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033765

InnateDB Gene

IDBG-154140 (Avpr2)

Protein Structure

UniProt Annotation

Function

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Involved in renal water reabsorption (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0005000	vasopressin receptor activity
GO:0005515	protein binding

Biological Process

GO:0003084	positive regulation of systemic arterial blood pressure
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0021537	telencephalon development
GO:0032609	interferon-gamma production
GO:0034097	response to cytokine
GO:0035811	negative regulation of urine volume
GO:0035814	negative regulation of renal sodium excretion
GO:0045777	positive regulation of blood pressure

Cellular Component

GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:88123

InterPro

IPR000161 Vasopressin V2 receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR001817 Vasopressin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00898
PR00237
PR00896

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O88721