InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Gucy1b3

Summary

InnateDB Gene

IDBG-154148.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gucy1b3

Gene Name

guanylate cyclase 1, soluble, beta 3

Synonyms

GC-S-beta-1; GCbeta1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000028005

Encoded Proteins

IDBP-154150

guanylate cyclase 1, soluble, beta 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000061918:
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998 [PubMed 9742212]).[supplied by OMIM, Mar 2008]
This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:82032004-82074711

Strand

Reverse strand

Band

Transcripts

ENSMUST00000029635

ENSMUSP00000029635

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004383	guanylate cyclase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0016849	phosphorus-oxygen lyase activity
GO:0020037	heme binding
GO:0043167	ion binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0051879	Hsp90 protein binding

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0007263	nitric oxide mediated signal transduction
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction