InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: GUCY1B1

Summary

InnateDB Gene

IDBG-630664.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GUCY1B1

Gene Name

Guanylate cyclase soluble subunit beta-1

Synonyms

GUCY1B1

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003840

Encoded Proteins

IDBP-682141

Guanylate cyclase soluble subunit beta-1

IDBP-682143

Guanylate cyclase soluble subunit beta-1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000061918:
Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha subunit and a beta subunit, typically GUCY1B3, catalyzes conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide (NO) and nitrovasodilator drugs (Zabel et al., 1998 [PubMed 9742212]).[supplied by OMIM, Mar 2008]
This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:44498805-44569575

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000062972	ENSBTAP00000055570
ENSBTAT00000005009	ENSBTAP00000005009

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004383	guanylate cyclase activity
GO:0005525	GTP binding
GO:0016829	lyase activity
GO:0016849	phosphorus-oxygen lyase activity
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0006810	transport
GO:0006811	ion transport
GO:0009190	cyclic nucleotide biosynthetic process
GO:0035556	intracellular signal transduction
GO:0055072	iron ion homeostasis