InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Arhgap4

Summary

InnateDB Gene

IDBG-154207.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arhgap4

Gene Name

Rho GTPase activating protein 4

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031389

Encoded Proteins

IDBP-154209

Rho GTPase activating protein 4

IDBP-251820

Rho GTPase activating protein 4

IDBP-251822

Rho GTPase activating protein 4

IDBP-251824

Rho GTPase activating protein 4

IDBP-251826

Rho GTPase activating protein 4

IDBP-533403

Rho GTPase activating protein 4

IDBP-541979

Rho GTPase activating protein 4

IDBP-537090

Rho GTPase activating protein 4

IDBP-537304

Rho GTPase activating protein 4

IDBP-534260

Rho GTPase activating protein 4

IDBP-533938

Rho GTPase activating protein 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000089820:
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:73891442-73921870

Strand

Reverse strand

Band

A7.3

Transcripts

ENSMUST00000064376	ENSMUSP00000067477
ENSMUST00000114407	ENSMUSP00000110049
ENSMUST00000114406	ENSMUSP00000110048
ENSMUST00000114405	ENSMUSP00000110047
ENSMUST00000114404	ENSMUSP00000110046
ENSMUST00000130976	ENSMUSP00000120650
ENSMUST00000148319
ENSMUST00000147510
ENSMUST00000127163
ENSMUST00000151600
ENSMUST00000145159
ENSMUST00000140393	ENSMUSP00000117602
ENSMUST00000142925
ENSMUST00000143696	ENSMUSP00000114877
ENSMUST00000149774	ENSMUSP00000115193
ENSMUST00000128329
ENSMUST00000143536
ENSMUST00000124798	ENSMUSP00000121215
ENSMUST00000149135
ENSMUST00000123283	ENSMUSP00000122794

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007399	nervous system development
GO:0010764	negative regulation of fibroblast migration
GO:0030517	negative regulation of axon extension
GO:0032321	positive regulation of Rho GTPase activity

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005874	microtubule
GO:0005925	focal adhesion
GO:0030426	growth cone