InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Malt1

Summary

InnateDB Gene

IDBG-154592.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Malt1

Gene Name

mucosa associated lymphoid tissue lymphoma translocation gene 1

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032688

Encoded Proteins

IDBP-154596

mucosa associated lymphoid tissue lymphoma translocation gene 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18192506

[Homo sapiens] MALT1 forms a complex with CARM1 and BCL10 to activate NF-kappaB.

PMID 20804738

[Homo sapiens] MALT1 is a paracaspase that has arginine-directed proteolytic activity. MALT1 cleaves TNFAIP3, a dual ubiquitin-editing enzyme involved in termination of NF-kappaB signalling, inducing cytosolic release of TNFAIP3 and dampening its inhibitory function.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172175:
This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:65430963-65478823

Strand

Forward strand

Band

Transcripts

ENSMUST00000049248

ENSMUSP00000048376

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004197	cysteine-type endopeptidase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0019209	kinase activator activity
GO:0043621	protein self-association

Biological Process

GO:0001923	B-1 B cell differentiation
GO:0002237	response to molecule of bacterial origin
GO:0002726	positive regulation of T cell cytokine production
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0009620	response to fungus
GO:0016567	protein ubiquitination
GO:0032743	positive regulation of interleukin-2 production
GO:0042098	T cell proliferation
GO:0042113	B cell activation
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response
GO:0050852	T cell receptor signaling pathway
GO:0050856	regulation of T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051168	nuclear export
GO:0051259	protein oligomerization