InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Malt1

Summary

InnateDB Protein

IDBP-154596.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Malt1

Protein Name

mucosa associated lymphoid tissue lymphoma translocation gene 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000048376

InnateDB Gene

IDBG-154592 (Malt1)

Protein Structure

UniProt Annotation

Function

Enhances BCL10-induced activation of NF-kappa-B. Involved in nuclear export of BCL10. Binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. Has ubiquitin ligase activity (By similarity). MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor- induced integrin adhesion (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250UniProtKB:Q9UDY8}. Note=Shuttles between the nucleus and cytoplasm. Found in perinuclear structures together with BCL10 (By similarity). {ECO:0000250UniProtKB:Q9UDY8}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	17 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	32 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004197	cysteine-type endopeptidase activity
GO:0004842	ubiquitin-protein transferase activity
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0019209	kinase activator activity
GO:0043621	protein self-association

Biological Process

GO:0001923	B-1 B cell differentiation
GO:0002237	response to molecule of bacterial origin
GO:0002726	positive regulation of T cell cytokine production
GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007249	I-kappaB kinase/NF-kappaB signaling
GO:0007250	activation of NF-kappaB-inducing kinase activity
GO:0009620	response to fungus
GO:0016567	protein ubiquitination
GO:0032743	positive regulation of interleukin-2 production
GO:0042098	T cell proliferation
GO:0042113	B cell activation
GO:0042981	regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response
GO:0050852	T cell receptor signaling pathway
GO:0050856	regulation of T cell receptor signaling pathway
GO:0050870	positive regulation of T cell activation
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051168	nuclear export
GO:0051259	protein oligomerization

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:2445027

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR013098 Immunoglobulin I-set
IPR013151 Immunoglobulin

PFAM

PF00656
PF07679
PF00047

PRINTS

PIRSF

SMART

SM00408
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q2TBA3