InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Kcnn4

Summary

InnateDB Gene

IDBG-154721.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Kcnn4

Gene Name

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

Synonyms

IK1; IKCA1; KCa3.1; KCA4; mIKCa1; SK4; SKCas

Species

Mus musculus

Ensembl Gene

ENSMUSG00000054342

Encoded Proteins

IDBP-624887

potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104783:
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:24370263-24385209

Strand

Forward strand

Band

Transcripts

ENSMUST00000171904

ENSMUSP00000133065

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015269	calcium-activated potassium channel activity
GO:0016286	small conductance calcium-activated potassium channel activity
GO:0019903	protein phosphatase binding
GO:0022894	Intermediate conductance calcium-activated potassium channel activity

Biological Process

GO:0002376	immune system process
GO:0006813	potassium ion transport
GO:0006816	calcium ion transport
GO:0006820	anion transport
GO:0006884	cell volume homeostasis
GO:0030322	stabilization of membrane potential
GO:0045332	phospholipid translocation
GO:0046541	saliva secretion
GO:0050714	positive regulation of protein secretion
GO:0050862	positive regulation of T cell receptor signaling pathway
GO:0071435	potassium ion export

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane
GO:0043025	neuronal cell body
GO:0045121	membrane raft

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000104783

View Gene Order

ENSBTAG00000004588

Not yet available

Pathways

NETPATH

REACTOME

REACT_202800

Potassium Channels pathway

REACT_199092

Ca2+ activated K+ channels pathway

REACT_259290

Neuronal System pathway

KEGG

mmu04974

Protein digestion and absorption pathway

mmu04970

Salivary secretion pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_75896

Ca2+ activated K+ channels pathway

REACT_13685

Neuronal System pathway

REACT_75908

Potassium Channels pathway

KEGG

hsa04970

Salivary secretion pathway

hsa04974

Protein digestion and absorption pathway

INOH

PID NCI

Cross-References

SwissProt

O89109

TrEMBL

D1MQ07

UniProt Splice Variant

Entrez Gene

16534

UniGene

Mm.402211 Mm.9911

RefSeq

NM_001163510 NM_008433 XM_006539563

OMIM

CCDS

CCDS20948

HPRD

IMGT

MGI ID

MGI:1277957

MGI Symbol

Kcnn4

EMBL

AB128930 AF042487 AF072884 AK010943 AK155910 BC010274 CH466593

GenPept

AAC32051 AAC32829 AAH10274 BAB27283 BAE33499 BAI52724 EDL24340

RNA Seq Atlas

16534