InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KCNN4

Summary

InnateDB Gene

IDBG-639154.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KCNN4

Gene Name

intermediate conductance calcium-activated potassium channel protein 4

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000004588

Encoded Proteins

IDBP-691304

intermediate conductance calcium-activated potassium channel protein 1

IDBP-691314

intermediate conductance calcium-activated potassium channel protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000104783:
The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:52303109-52316896

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000006024	ENSBTAP00000006024
ENSBTAT00000054964	ENSBTAP00000048269

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005267	potassium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0015269	calcium-activated potassium channel activity
GO:0016286	small conductance calcium-activated potassium channel activity
GO:0019903	protein phosphatase binding
GO:0022894	Intermediate conductance calcium-activated potassium channel activity

Biological Process

GO:0006813	potassium ion transport
GO:0006816	calcium ion transport
GO:0006884	cell volume homeostasis
GO:0030322	stabilization of membrane potential
GO:0045332	phospholipid translocation
GO:0046541	saliva secretion
GO:0050714	positive regulation of protein secretion
GO:0050862	positive regulation of T cell receptor signaling pathway
GO:0071805	potassium ion transmembrane transport