InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Muc20

Summary

InnateDB Gene

IDBG-154788.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Muc20

Gene Name

mucin 20

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000035638

Encoded Proteins

IDBP-154790

mucin 20

IDBP-250347

mucin 20

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000176945:
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The shorter isoform expressed by this gene is localized to the plasma membrane, whereas the longer isoform might be secreted. The C terminus of this protein associates with the multifunctional docking site of the met proto-oncogene and suppresses activation of some downstream met signaling cascades. The protein features a tandem repeat domain that varies between 2 and 6 copies in most individuals. The allele represented in the human reference assembly contains 12 copies. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:32777419-32797435

Strand

Reverse strand

Band

Transcripts

ENSMUST00000041123	ENSMUSP00000041221
ENSMUST00000115116	ENSMUSP00000110769

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0043065	positive regulation of apoptotic process
GO:0048012	hepatocyte growth factor receptor signaling pathway
GO:0051260	protein homooligomerization

Cellular Component

GO:0005576	extracellular region
GO:0005741	mitochondrial outer membrane
GO:0005829	cytosol
GO:0009925	basal plasma membrane
GO:0016324	apical plasma membrane
GO:0031528	microvillus membrane