Version 5.4
Homo sapiens Gene: MUC20
Summary
InnateDB Gene IDBG-70656.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MUC20
Gene Name mucin 20, cell surface associated
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000176945
Encoded Proteins
IDBP-70660
mucin 20, cell surface associated
IDBP-386863
mucin 20, cell surface associated
IDBP-386864
mucin 20, cell surface associated
IDBP-386865
mucin 20, cell surface associated
IDBP-386866
mucin 20, cell surface associated
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The shorter isoform expressed by this gene is localized to the plasma membrane, whereas the longer isoform might be secreted. The C terminus of this protein associates with the multifunctional docking site of the met proto-oncogene and suppresses activation of some downstream met signaling cascades. The protein features a tandem repeat domain that varies between 2 and 6 copies in most individuals. The allele represented in the human reference assembly contains 12 copies. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:195720882-195741123
Strand Forward strand
Band q29
Transcripts
ENST00000320736 ENSP00000325431
ENST00000447234 ENSP00000414350
ENST00000436408 ENSP00000396774
ENST00000445522 ENSP00000405629
ENST00000423938 ENSP00000397774
ENST00000485430
ENST00000480350
ENST00000498018
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0016266 O-glycan processing
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0051260 protein homooligomerization
Cellular Component
GO:0005576 extracellular region
GO:0005796 Golgi lumen
GO:0009925 basal plasma membrane
GO:0016324 apical plasma membrane
GO:0031528 microvillus membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035638
View Gene Order
ENSBTAG00000032819
Not yet available
Pathways
NETPATH
REACTOME
REACT_115835
Termination of O-glycan biosynthesis pathway
REACT_115606
O-linked glycosylation of mucins pathway
REACT_22161
Post-translational protein modification pathway
REACT_200727
O-linked glycosylation pathway
REACT_17015
Metabolism of proteins pathway
KEGG
INOH
PID NCI
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Cross-References
SwissProt Q8N307
TrEMBL C9JJE7 E9PH32 I0CMJ9 I0CMK3 I0EZ59 I0EZ60
UniProt Splice Variant
Entrez Gene 200958
UniGene Hs.308992 Hs.716831 Hs.739367
RefSeq NM_001282506 NM_001291833 NM_152673
HUGO HGNC:23282
OMIM 610360
CCDS CCDS63877
HPRD
IMGT
EMBL AB037780 AB098731 AB098733 AC069513 AC233280 AK027314 AK075138 AY358449 BC029267 BC044243 JQ411644 JQ411645 JQ582411 JQ582415
GenPept AAH29267 AAH44243 AAQ88814 AFH78580 AFH78584 AFI24895 AFI24896 BAA92597 BAB55035 BAC11428 BAD06718 BAD06720
RNA Seq Atlas 200958

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca