Mus musculus Gene: Wwc2
Summary
InnateDB Gene IDBG-154801.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wwc2
Gene Name WW, C2 and coiled-coil domain containing 2
Synonyms 5330431C14Rik; AU022508; C85457; D8Ertd594e
Species Mus musculus
Ensembl Gene ENSMUSG00000031563
Encoded Proteins
WW, C2 and coiled-coil domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000151718:
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:47826083-47990543
Strand Reverse strand
Band B1.1
Transcripts
ENSMUST00000057561 ENSMUSP00000056121
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0032947 protein complex scaffold
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0008150 biological_process
GO:0035331 negative regulation of hippo signaling
GO:0046621 negative regulation of organ growth
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
Cell adhesion molecules (CAMs) pathway
Leukocyte transendothelial migration pathway
Tight junction pathway
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.235074 Mm.481201
RefSeq NM_133791
OMIM
CCDS CCDS22301
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas