Version 5.4
Homo sapiens Gene: WWC2
Summary
InnateDB Gene IDBG-45849.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol WWC2
Gene Name WW and C2 domain containing 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151718
Encoded Proteins
IDBP-294920
WW and C2 domain containing 2
IDBP-380017
WW and C2 domain containing 2
IDBP-380023
WW and C2 domain containing 2
IDBP-380024
WW and C2 domain containing 2
IDBP-473930
WW and C2 domain containing 2
IDBP-477977
WW and C2 domain containing 2
IDBP-477221
WW and C2 domain containing 2
IDBP-477417
WW and C2 domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is intronless and overlaps the 3' UTR of the WWC2 gene (GeneID: 80014) on the opposite strand. [provided by RefSeq, Aug 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:183099293-183320777
Strand Forward strand
Band q35.1
Transcripts
ENST00000403733 ENSP00000384222
ENST00000448232 ENSP00000398577
ENST00000427431 ENSP00000393342
ENST00000438543 ENSP00000413521
ENST00000508614 ENSP00000423238
ENST00000513834 ENSP00000425054
ENST00000504005 ENSP00000427569
ENST00000506225
ENST00000515284
ENST00000508747 ENSP00000420835
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019900 kinase binding
GO:0032947 protein complex scaffold
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0035331 negative regulation of hippo signaling
GO:0046621 negative regulation of organ growth
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031563
View Gene Order
ENSBTAG00000012191
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04530
Tight junction pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.333179 Hs.715996
RefSeq NM_024949
HUGO
OMIM
CCDS CCDS34109
HPRD 12529
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca