Version 5.4
Mus musculus Gene: Maf1
Summary
InnateDB Gene IDBG-154807.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Maf1
Gene Name MAF1 homolog (S. cerevisiae)
Synonyms 1110068E11Rik; AU042856
Species Mus musculus
Ensembl Gene ENSMUSG00000022553
Encoded Proteins
IDBP-154809
MAF1 homolog (S. cerevisiae)
IDBP-537764
MAF1 homolog (S. cerevisiae)
IDBP-534481
MAF1 homolog (S. cerevisiae)
IDBP-539956
MAF1 homolog (S. cerevisiae)
IDBP-538912
MAF1 homolog (S. cerevisiae)
IDBP-540044
MAF1 homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179632:
This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:76351294-76354380
Strand Forward strand
Band D3
Transcripts
ENSMUST00000023212 ENSMUSP00000023212
ENSMUST00000160853 ENSMUSP00000124893
ENSMUST00000161527 ENSMUSP00000125387
ENSMUST00000162871
ENSMUST00000160172 ENSMUSP00000124242
ENSMUST00000160857
ENSMUST00000160097
ENSMUST00000161786
ENSMUST00000160914 ENSMUSP00000124110
ENSMUST00000160069
ENSMUST00000162865
ENSMUST00000161391
ENSMUST00000160875
ENSMUST00000161072 ENSMUSP00000125332
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001030 RNA polymerase III type 1 promoter DNA binding
GO:0001031 RNA polymerase III type 2 promoter DNA binding
GO:0001032 RNA polymerase III type 3 promoter DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0016480 negative regulation of transcription from RNA polymerase III promoter
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0030424 axon
GO:0030425 dendrite
GO:0060077 inhibitory synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000179632
View Gene Order
ENSBTAG00000012242
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 68877
UniGene Mm.289680 Mm.470647
RefSeq NM_001164607 NM_001164608 NM_026859
OMIM
CCDS CCDS27568
HPRD
IMGT
MGI ID MGI:1916127
MGI Symbol Maf1
EMBL
GenPept
RNA Seq Atlas 68877

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca