Version 5.4
Mus musculus Gene: Axin1
Summary
InnateDB Gene IDBG-154815.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Axin1
Gene Name axin 1
Synonyms AI316800; Axin; Fu; fused; Kb; Ki; kinky; knobbly
Species Mus musculus
Ensembl Gene ENSMUSG00000024182
Encoded Proteins
IDBP-154817
axin 1
IDBP-401406
axin 1
IDBP-624331
axin 1
IDBP-624332
axin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000103126:
This gene encodes a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain. The encoded protein interacts with adenomatosis polyposis coli, catenin beta-1, glycogen synthase kinase 3 beta, protein phosphate 2, and itself. This protein functions as a negative regulator of the wingless-type MMTV integration site family, member 1 (WNT) signaling pathway and can induce apoptosis. The crystal structure of a portion of this protein, alone and in a complex with other proteins, has been resolved. Mutations in this gene have been associated with hepatocellular carcinoma, hepatoblastomas, ovarian endometriod adenocarcinomas, and medullablastomas. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:26138688-26195811
Strand Forward strand
Band A3.3
Transcripts
ENSMUST00000074370 ENSMUSP00000073974
ENSMUST00000118904 ENSMUSP00000113756
ENSMUST00000163421 ENSMUSP00000132000
ENSMUST00000168282 ENSMUSP00000127182
ENSMUST00000169268
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.
Experimentally validated
Total 72 [view]
Protein-Protein 67 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 5 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 67 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0002039 p53 binding
GO:0004871 signal transducer activity
GO:0005096 GTPase activator activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0008022 protein C-terminus binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
GO:0031625 ubiquitin protein ligase binding
GO:0032947 protein complex scaffold
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0043621 protein self-association
GO:0046332 SMAD binding
GO:0070016 armadillo repeat domain binding
GO:0070411 I-SMAD binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000209 protein polyubiquitination
GO:0001701 in utero embryonic development
GO:0001743 optic placode formation
GO:0001932 regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0006913 nucleocytoplasmic transport
GO:0006915 apoptotic process
GO:0007257 activation of JUN kinase activity
GO:0007275 multicellular organismal development
GO:0007368 determination of left/right symmetry
GO:0007605 sensory perception of sound
GO:0008219 cell death
GO:0009950 dorsal/ventral axis specification
GO:0009953 dorsal/ventral pattern formation
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0016055 Wnt signaling pathway
GO:0021797 forebrain anterior/posterior pattern specification
GO:0021881 Wnt receptor signaling pathway involved in forebrain neuron fate commitment
GO:0030163 protein catabolic process
GO:0030178 negative regulation of Wnt signaling pathway
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030910 olfactory placode formation
GO:0031122 cytoplasmic microtubule organization
GO:0031398 positive regulation of protein ubiquitination
GO:0032147 activation of protein kinase activity
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter
GO:0035412 regulation of catenin import into nucleus
GO:0036342 post-anal tail morphogenesis
GO:0038032 termination of G-protein coupled receptor signaling pathway
GO:0043507 positive regulation of JUN kinase activity
GO:0043547 positive regulation of GTPase activity
GO:0043623 cellular protein complex assembly
GO:0045599 negative regulation of fat cell differentiation
GO:0045860 positive regulation of protein kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0046330 positive regulation of JNK cascade
GO:0048048 embryonic eye morphogenesis
GO:0048318 axial mesoderm development
GO:0048320 axial mesoderm formation
GO:0051248 negative regulation of protein metabolic process
GO:0051260 protein homooligomerization
GO:0051443 positive regulation of ubiquitin-protein transferase activity
GO:0055001 muscle cell development
GO:0060070 canonical Wnt signaling pathway
GO:0060823 canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO:0071407 cellular response to organic cyclic compound
GO:0071514 genetic imprinting
GO:0090090 negative regulation of canonical Wnt signaling pathway
GO:0090244 Wnt signaling pathway involved in somitogenesis
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005881 cytoplasmic microtubule
GO:0005886 plasma membrane
GO:0005938 cell cortex
GO:0014069 postsynaptic density
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0016328 lateral plasma membrane
GO:0030877 beta-catenin destruction complex
GO:0031410 cytoplasmic vesicle
GO:0043234 protein complex
GO:0048471 perinuclear region of cytoplasm
GO:0071944 cell periphery
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000103126
View Gene Order
ENSBTAG00000016577
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_258066
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_214014
Signaling by Wnt pathway
REACT_218396
Beta-catenin phosphorylation cascade pathway
REACT_233046
Signaling by WNT in cancer pathway
REACT_203336
Degradation of beta-catenin by the destruction complex pathway
REACT_235529
AMER1 mutants destabilize the destruction complex pathway
REACT_231507
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_258576
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_230286
APC truncation mutants have impaired AXIN binding pathway
REACT_262115
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_241644
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_241514
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_216784
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_236203
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_234076
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_252458
AXIN missense mutants destabilize the destruction complex pathway
REACT_207044
TCF dependent signaling in response to WNT pathway
REACT_263691
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_248000
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_261276
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_254498
TCF7L2 mutants don't bind CTBP pathway
REACT_250714
truncations of AMER1 destabilize the destruction complex pathway
REACT_219129
degradation of AXIN pathway
REACT_188257
Signal Transduction pathway
REACT_237096
truncated APC mutants destabilize the destruction complex pathway
REACT_260752
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_241402
XAV939 inhibits tankyrase, stabilizing AXIN pathway
KEGG
mmu05213
Endometrial cancer pathway
mmu05217
Basal cell carcinoma pathway
mmu04310
Wnt signaling pathway pathway
mmu05210
Colorectal cancer pathway
mmu05200
Pathways in cancer pathway
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_7
TGF_beta_Receptor pathway
NetPath_8
Wnt pathway
REACTOME
REACT_11065
Beta-catenin phosphorylation cascade pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_200610
disassembly of the destruction complex and recruitment of AXIN to the membrane pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_111102
Signal Transduction pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_200766
degradation of AXIN pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
KEGG
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa05213
Endometrial cancer pathway
hsa05217
Basal cell carcinoma pathway
hsa05200
Pathways in cancer pathway
INOH
INOH website
Wnt signaling pathway pathway
PID NCI
ps1pathway
Presenilin action in Notch and Wnt signaling
myc_pathway
C-MYC pathway
wnt_canonical_pathway
Canonical Wnt signaling pathway
tgfbrpathway
TGF-beta receptor signaling
betacatenin_deg_pathway
Degradation of beta catenin
ncadherinpathway
N-cadherin signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.23684
RefSeq NM_001159598 NM_009733 XM_006523515 XM_006523516
OMIM
CCDS CCDS28547 CCDS50042
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca