InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Axin1

Summary

InnateDB Protein

IDBP-154817.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Axin1

Protein Name

axin 1

Synonyms

AI316800; Axin; Fu; fused; Kb; Ki; kinky; knobbly;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073974

InnateDB Gene

IDBG-154815 (Axin1)

Protein Structure

UniProt Annotation

Function

Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling (By similarity). Controls dorsoventral patterning via two opposing effects; down- regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. In Wnt signaling, probably facilitates the phosphorylation of CTNNB1 and APC by GSK3B. Likely to function as a tumor suppressor. Facilitates the phosphorylation of TP53 by HIPK2 upon ultraviolet irradiation. Enhances TGF-beta signaling by recruiting the RNF111 E3 ubiquitin ligase and promoting the degradation of inhibitory SMAD7 (By similarity). Also component of the AXIN1-HIPK2-TP53 complex which controls cell growth, apoptosis and development. {ECO:0000250, ECO:0000269PubMed:12223491, ECO:0000269PubMed:15526030, ECO:0000269PubMed:17681137}.

Subcellular Localization

Cytoplasm. Nucleus {ECO:0000250}. Cell membrane. Membrane. Note=On UV irradiation, translocates to the nucleus and colocalizes with DAAX (By similarity). MACF1 is required for its translocation to cell membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in embryonic stem cells.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 67 interaction(s) predicted by orthology.

Experimentally validated
Total	72 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	5 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	67 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0004871	signal transducer activity
GO:0005096	GTPase activator activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008022	protein C-terminus binding
GO:0019899	enzyme binding
GO:0019901	protein kinase binding
GO:0019904	protein domain specific binding
GO:0031625	ubiquitin protein ligase binding
GO:0032947	protein complex scaffold
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0043621	protein self-association
GO:0046332	SMAD binding
GO:0070016	armadillo repeat domain binding
GO:0070411	I-SMAD binding
GO:0070412	R-SMAD binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0001701	in utero embryonic development
GO:0001743	optic placode formation
GO:0001932	regulation of protein phosphorylation
GO:0001934	positive regulation of protein phosphorylation
GO:0006913	nucleocytoplasmic transport
GO:0006915	apoptotic process
GO:0007257	activation of JUN kinase activity
GO:0007275	multicellular organismal development
GO:0007368	determination of left/right symmetry
GO:0007605	sensory perception of sound
GO:0008219	cell death
GO:0009950	dorsal/ventral axis specification
GO:0009953	dorsal/ventral pattern formation
GO:0010800	positive regulation of peptidyl-threonine phosphorylation
GO:0016055	Wnt signaling pathway
GO:0021797	forebrain anterior/posterior pattern specification
GO:0021881	Wnt receptor signaling pathway involved in forebrain neuron fate commitment
GO:0030163	protein catabolic process
GO:0030178	negative regulation of Wnt signaling pathway
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030910	olfactory placode formation
GO:0031122	cytoplasmic microtubule organization
GO:0031398	positive regulation of protein ubiquitination
GO:0032147	activation of protein kinase activity
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter
GO:0035412	regulation of catenin import into nucleus
GO:0036342	post-anal tail morphogenesis
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043507	positive regulation of JUN kinase activity
GO:0043547	positive regulation of GTPase activity
GO:0043623	cellular protein complex assembly
GO:0045599	negative regulation of fat cell differentiation
GO:0045860	positive regulation of protein kinase activity
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046330	positive regulation of JNK cascade
GO:0048048	embryonic eye morphogenesis
GO:0048318	axial mesoderm development
GO:0048320	axial mesoderm formation
GO:0051248	negative regulation of protein metabolic process
GO:0051260	protein homooligomerization
GO:0051443	positive regulation of ubiquitin-protein transferase activity
GO:0055001	muscle cell development
GO:0060070	canonical Wnt signaling pathway
GO:0060823	canonical Wnt receptor signaling pathway involved in neural plate anterior/posterior pattern formation
GO:0071407	cellular response to organic cyclic compound
GO:0071514	genetic imprinting
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:0090244	Wnt signaling pathway involved in somitogenesis
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005881	cytoplasmic microtubule
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0014069	postsynaptic density
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0016328	lateral plasma membrane
GO:0030877	beta-catenin destruction complex
GO:0031410	cytoplasmic vesicle
GO:0043234	protein complex
GO:0048471	perinuclear region of cytoplasm
GO:0071944	cell periphery

Protein Structure and Domains

PDB ID

MGI:1096327

InterPro

IPR000342 Regulator of G protein signalling domain
IPR001158 DIX domain
IPR014936 Axin beta-catenin binding
IPR016137 Regulator of G protein signalling superfamily

PFAM

PF00615
PF00778
PF08833

PRINTS

PR01301

PIRSF

SMART

SM00021
SM00315

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt