Mus musculus Gene: Whrn
Summary
InnateDB Gene IDBG-154965.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Whrn
Gene Name whirlin
Synonyms 1110035G07Rik; AW122018; AW742671; C430046P22Rik; Dfnb31; wi;
Species Mus musculus
Ensembl Gene ENSMUSG00000039137
Encoded Proteins
Protein Structure
Entrez Gene
Summary This gene encodes a protein required for elongation and actin polymerization in the hair cell stereocilia. The encoded protein is localized to the cytoplasm and co-localizes with the growing end of actin filaments. Mutations in this gene have been linked to deafness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:63414910-63495991
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000084510 ENSMUSP00000081557
ENSMUST00000063650 ENSMUSP00000069664
ENSMUST00000095038 ENSMUSP00000092648
ENSMUST00000095037 ENSMUSP00000092647
ENSMUST00000102867 ENSMUSP00000099931
ENSMUST00000063672 ENSMUSP00000065838
ENSMUST00000107393 ENSMUSP00000103016
ENSMUST00000119294 ENSMUSP00000114030
ENSMUST00000155058
ENSMUST00000145133
ENSMUST00000124016
ENSMUST00000145630 ENSMUSP00000116387
ENSMUST00000148957
ENSMUST00000153307
ENSMUST00000144965 ENSMUSP00000121944
ENSMUST00000133425 ENSMUSP00000119280
ENSMUST00000140720
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0001895 retina homeostasis
GO:0007605 sensory perception of sound
GO:0050953 sensory perception of light stimulus
GO:0060122 inner ear receptor stereocilium organization
Cellular Component
GO:0001917 photoreceptor inner segment
GO:0002142 stereocilia ankle link complex
GO:0005581 collagen
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0005929 cilium
GO:0030424 axon
GO:0030426 growth cone
GO:0032391 photoreceptor connecting cilium
GO:0032420 stereocilium
GO:0032421 stereocilium bundle
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q80VW5
TrEMBL I6MML7 I7HII7 I7HIR4 I7HJT2 I7HNW6 J3JSA5
UniProt Splice Variant
Entrez Gene 73750
UniGene Mm.300397 Mm.449056
RefSeq NM_001008791 NM_001008792 NM_001008793 NM_001008794 NM_001008795 NM_001008796 NM_028640
OMIM
CCDS CCDS18255 CCDS18256 CCDS18257 CCDS18258 CCDS18259 CCDS38778 CCDS51204
HPRD
IMGT
MGI ID 2682003 MGI:2682003
MGI Symbol Whrn
EMBL AK122523 AK157955 AL683828 AY739114 AY739115 AY739116 AY739117 AY739118 AY739119 AY739120 AY739121 AY739122 HQ148553
GenPept AAV87519 AAV87520 AAV87521 AAV87522 AAV87523 AAV87524 AAV87525 AAV87526 AAV87527 AEL23235 BAC65805 BAE34281 CAD62267 CAD62268 CAM21546 CAM21547 CAM21548 CAP19264 CAP19265 CAP19266 CAP19267 CAP19268
ImmGen Whrn (murine)
RNA Seq Atlas 73750