Mus musculus Gene: Whrn

Summary
InnateDB Gene IDBG-154965.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol Whrn
Gene Name whirlin
Synonyms 1110035G07Rik; AW122018; AW742671; C430046P22Rik; Dfnb31; wi
Species Mus musculus
Ensembl Gene ENSMUSG00000039137
Encoded Proteins
IDBP-154967 whirlin
IDBP-154969 whirlin
IDBP-154971 whirlin
IDBP-154973 whirlin
IDBP-154975 whirlin
IDBP-154979 whirlin
IDBP-266763 whirlin
IDBP-400747 whirlin
IDBP-540176 whirlin
IDBP-535713 whirlin
IDBP-534563 whirlin
Entrez Gene
Summary This gene encodes a protein required for elongation and actin polymerization in the hair cell stereocilia. The encoded protein is localized to the cytoplasm and co-localizes with the growing end of actin filaments. Mutations in this gene have been linked to deafness. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 4: 63414910-63495991
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000084510  ENSMUSP00000081557
ENSMUST00000063650  ENSMUSP00000069664
ENSMUST00000095038  ENSMUSP00000092648
ENSMUST00000095037  ENSMUSP00000092647
ENSMUST00000102867  ENSMUSP00000099931
ENSMUST00000063672  ENSMUSP00000065838
ENSMUST00000107393  ENSMUSP00000103016
ENSMUST00000119294  ENSMUSP00000114030
ENSMUST00000155058 
ENSMUST00000145133 
ENSMUST00000124016 
ENSMUST00000145630  ENSMUSP00000116387
ENSMUST00000148957 
ENSMUST00000153307 
ENSMUST00000144965  ENSMUSP00000121944
ENSMUST00000133425  ENSMUSP00000119280
ENSMUST00000140720 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein‑Protein  8
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0005515 protein binding
GO:0019904 protein domain specific binding
Biological Process
GO:0001895 retina homeostasis
GO:0007605 sensory perception of sound
GO:0050953 sensory perception of light stimulus
GO:0060122 inner ear receptor stereocilium organization
Cellular Component
GO:0001917 photoreceptor inner segment
GO:0002142 stereocilia ankle link complex
GO:0005581 collagen
GO:0005737 cytoplasm
GO:0005884 actin filament
GO:0005929 cilium
GO:0030424 axon
GO:0030426 growth cone
GO:0032391 photoreceptor connecting cilium
GO:0032420 stereocilium
GO:0032421 stereocilium bundle
GO:0043025 neuronal cell body
GO:0043198 dendritic shaft
GO:0045202 synapse
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSG00000095397 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000010107 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q80VW5 
TrEMBL I6MML7 I7HII7 I7HIR4 I7HJT2 I7HNW6 J3JSA5
UniProt Splice Variant
Entrez Gene 73750 
UniGene Mm.300397 Mm.449056
RefSeq NM_001008791  NM_001008792  NM_001008793  NM_001008794  NM_001008795  NM_001008796  NM_028640 
OMIM
CCDS CCDS18255  CCDS18256  CCDS18257  CCDS18258  CCDS18259  CCDS38778  CCDS51204 
HPRD
IMGT
MGI ID MGI:2682003 
MGI Symbol Whrn
EMBL AK122523 AK157955 AL683828 AY739114 AY739115 AY739116 AY739117 AY739118 AY739119 AY739120 AY739121 AY739122 HQ148553
GenPept AAV87519  AAV87520  AAV87521  AAV87522  AAV87523  AAV87524  AAV87525  AAV87526  AAV87527  AEL23235  BAC65805  BAE34281  CAD62267  CAD62268  CAM21546  CAM21547  CAM21548  CAP19264  CAP19265  CAP19266  CAP19267  CAP19268 
ImmGen Whrn (murine) 
RNA Seq Atlas 73750